MOTS-c

What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide, and that phrase is doing more work than it appears to. Nearly every peptide in the body is encoded by nuclear DNA. MOTS-c is encoded in mitochondrial DNA, a remnant of the fact that mitochondria were once independent organisms with their own genome.

That makes it a signal originating inside the mitochondria and acting outward on the rest of the cell, which is an unusual direction of traffic in cellular signalling and the reason the compound attracted attention.

MOTS-c research applications

Published research covers metabolic regulation, insulin sensitivity, and the cellular response to metabolic stress. Levels appear to decline with age, following a pattern seen with several compounds studied in longevity contexts.

Because the mechanism sits at the intersection of metabolism and cellular energy production, MOTS-c appears in both metabolic research and mitochondrial ageing research rather than belonging cleanly to either.

How MOTS-c works

Research describes MOTS-c influencing metabolic pathways including AMPK signalling, a central regulator of cellular energy balance that responds to the ratio of available energy in the cell. It has also been studied in relation to nuclear gene expression, which is what makes the mitochondria-to-nucleus signalling direction interesting.

The literature is early. It is also mechanistically distinct enough that dismissing it would be as much of a mistake as overselling it.

MOTS-c peptide for sale: specifications

MOTS-c vs SS-31

Both compounds appear in our guide to the best peptides for energy.

Reconstitution and handling

Supplied lyophilized. Reconstitute with bacteriostatic water, adding diluent slowly against the vial wall and allowing the powder to dissolve undisturbed. Bacteriostatic water is stocked separately.

Storage and stability

Store sealed lyophilized vials at minus 20 degrees Celsius, away from light. Reconstituted solution needs refrigeration and has a shorter usable window. Avoid repeated freeze and thaw cycles.

Certificate of analysis for every batch

Independent third-party testing on every batch, HPLC purity to a minimum of 98% and identity confirmed by mass spectrometry, with certificates published at our research page before purchase.

Why researchers buy MOTS-c from Healio

Published certificates from an unaffiliated laboratory, verified purity and identity, US dispatch, and a curated catalog. MOTS-c sits in both peptides for energy and anti-aging peptides, since the research spans both.

MOTS-c FAQ

What is MOTS-c used for in research?

Metabolic regulation, insulin sensitivity and mitochondrial signalling research. Supplied as a laboratory research material only.

Why is MOTS-c called a mitochondrial-derived peptide?

Because it is encoded in mitochondrial DNA rather than nuclear DNA, which is unusual and means it signals outward from the mitochondria to the rest of the cell.

How does MOTS-c compare to SS-31?

Both concern mitochondria but through different mechanisms. MOTS-c is studied for metabolic signalling; SS-31 targets cardiolipin in the inner mitochondrial membrane and has the more formal clinical development history.

What purity is Healio MOTS-c?

Minimum 98% by HPLC with mass spectrometry identity confirmation from an independent laboratory, published per batch.